Periodontitis is a destructive disease that causes irreversible damage to periodontal supporting tissues, posing a serious threat to patients' oral health. Given the insidious nature of periodontal tissue destruction, early diagnosis of periodontitis is crucial. Salivary H₂S has been identified as a potential biomarker for periodontitis monitoring. However, existing detection methods struggle to precisely locate the source of H₂S release within the oral cavity, making it difficult to accurately identify affected areas and significantly hindering early diagnosis and treatment of periodontitis. This study reported a visual fluorescent probe (TTN) with AIE characteristics, which exhibited high sensitivity and rapid responsiveness to H₂S, along with dual-signal response capabilities in both ultraviolet and fluorescence spectra. Based on this probe, a highly reliable and practical TTN films sensor capable of efficiently monitoring H₂S is developed. Leveraging its excellent performance, TTN films could be used for real-time diagnosis of periodontitis, allowing precise identification of diseased tooth areas through visible color and fluorescence changes. Additionally, the film demonstrated efficient reactive oxygen species (ROS) generation, effectively inhibiting the growth of periodontitis-causing bacteria and showcasing therapeutic potential. This integrated diagnostic and therapeutic design not only provides a novel approach for monitoring H₂S as a biomarker but also opens new avenues for precise diagnosis and treatment of periodontitis.

原文链接：https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502710